first place, to the natural or legal persons that manufacture or import substances, but only
when they do so in quantities exceeding a certain volume, to enable them to carry the
associated burden. natural or legal persons handling chemicals should take the necessary
risk management measures in accordance with the assessment of the risks of substances
and pass on relevant recommendations along the supply chain. this should include
describing, documenting and notifying in an appropriate and transparent fashion the risks
stemming from the production, use and disposal of each substance.