作者：coleenrkaiser1,michellelflenniken2,3,ericgillitzer3,4,annlharmsen1,allengharmsen1,markajutila1,trevordouglas3,5,markjyoung3,4
1departmentofveterinarymolecularbiology;2departmentofmicrobiology;3centerforbio-inspirednanomaterials;4departmentofplantsciences;and5departmentofchemistryandbiochemistry,montanastateuniversity,bozeman,montana,usa
摘要：proteincagenanoparticleshavethepotentialtoserveasmultifunctionalcelltargeted,imagingandtherapeuticplatformsforbroadapplicationsinmedicine.however,beforetheyfindapplicationsinmedicine,theirbiocompatibilityinvivoneedstobedemonstrated.weprovideherebaselinebiodistributioninformationoftwodifferentsphericalproteincagenanoplatforms,the28nmviralcowpeachloroticmottlevirus(ccmv)andthe12nmheatshockprotein(hsp)cage.inna飗eandimmunizedmicebothnanoplatformsshowsimilarbroaddistributionandmovementthroughoutmosttissuesandorgans,rapidexcretion,theabsenceoflongtermpersistencewithinmicetissueandorgans,andnooverttoxicityafterasingleinjection.theseresultssuggestthatproteincagebasednanoparticlesmayserveassafe,biocompatible,nanoplatformsforapplicationsinmedicine.
关键词：proteincagenanoparticles,cowpeachloroticmottlevirus,heatshockprotein,biodistribution