catalog number : byk-0094r
quantity size : 0.1ml (1mg/ml,lyophilized or liquid.buffer=0.01m pbs,ph 7.4 with 10 mg/ml bsa and 0.1% sodium azide.reconstitute with 0.1ml sterile distilled water.)
background: alpha 1-antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin g and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. it contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with alzheimers disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. these observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of alzheimers disease.
specificity :
is a rabbit polyclonal antibody unconjugated specific for alpha-1-antichymotrypsin of human,use for western blotting,elisa,immunoprecipitation and immunohistochemistryprotein g affinity chromatography purification, purity :>95%isotype: iggmol wt: 45kdaapplication :
western blotting=1:100-500 immunohistocry 1:100-500 elisa= 1:500-1000ihc-p=1:100-500ihc-f=1:100-500if=1:100-500optimal working dilutions must be determined by the end user.
storage: store at -20℃ for one year. avoid repeated freeze/thaw cycles. the lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. when reconstituted in sterile ph 7.4 0.01m pbs or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
important note: this product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.