文献名：afullerene−paclitaxelchemotherapeutic: synthesis,characterization,andstudyofbiologicalactivityintissueculture
作者：tatianay.zakharian,alexanderseryshev,balajisitharaman,briane.gilbert,vernonknight,andlonj.wilson
departmentofchemistryandthecenterofnanoscalescienceandtechnology,riceuniversity,p.o.box1892,houston,texas77251-1892,departmentofmolecularphysiologyandbiophysics,baylorcollegeofmedicine,onebaylorplaza,houston,texas77030,anddepartmentofmolecularvirologyandmicrobiology,baylorcollegeofmedicine,onebaylorplaza,houston,texas77030
摘要：afullerene−paclitaxelconjugatehasbeensynthesizedasaslow-releasedrugforaerosolliposomedeliveryofpaclitaxelforlungcancertherapy.theconjugatewasdesignedtoreleasepaclitaxelviaenzymatichydrolysisandsubsequentlyhasshownahalf-lifeofreleaseof80mininbovineplasma.aliposomeformulationoftheconjugatehasbeenpreparedusingdilauroylphosphatidylcholine(dlpc),anditsic50isvirtuallyidenticaltotheic50forapaclitaxel−dlpcformulationinhumanepitheliallungcarcinomaa549cells.withbothclinicallyrelevantkineticsofhydrolysisandsignificantcytotoxicityintissueculture,theconjugateholdspromiseforenhancedtherapeuticefficacyofpaclitaxelinvivo.