cat. number: rs-11296r
quantity size: 0.1ml（dilute with ph 7.4 0.01 m pbs or diluent of antibody）
background: 17beta-hsd4 （17beta-hydroxysteroid dehydrogenase type 4） is also known as peroxisomal multifunctional enzyme/protein 2 （mfe-2/mfp-2）, d-bifunctional enzyme or 17-beta estradiol dehydrogenase type iv. it belongs to the 17beta-hsd family of proteins that regulate the availability of steroids within various tissues throughout the body. 17beta-hsd4 inactivates estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol beta-oxidation. it has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17beta-hsd4 is a target protein of chromeceptin and it is essential for the downstream activation of stat6. 17beta-hsd4-deficient patients exhibit zellweger-like syndrome and die within the first year of life. they display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
specificity: ·anti- hsd17b4 is a rabbit monoclonal antibody unconjugated
·specific for hsd17b4 of rat and mo
·epitope mapping near the amino terminus of hsd17b4 of
hu, rat and mo origin
· use for western blotting, elisa, immunoprecipitation
and immunohistochemistry
·protein a affinity chromatography purification, purity :>95%
hsd17b4抗体，hsd17b4抗体说明书 · isotype: igg
· mol wt: 47kda
application: · western blotting: 1:100-500
· immunohistochemistry: 1:100-500
· elisa: 1:500-1000
·optimal working dilutions must be determined by the end user.
hsd17b4抗体，hsd17b4抗体说明书 storage: store at –20 ºc for one year. avoid repeated freeze/thaw cycles. the lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºc. when reconstituted in sterile ph 7.4 0.01m pbs or diluent of antibody the antibody is stable for at least two weeks at 2-4 ºc.
important note:this product as supplied isintended for research use only, not for use in human, therapeutic or diagnostic applications.
hsd17b4抗体，hsd17b4抗体说明书