catalog number : byk-7058r-pe
quantity size : 100ug (2mg/1ml, lyophilized or liquid.buffer=preservative:15mm.sodium azide,constiyuents:1% bsa, 0.01m pbs, ph 7.4. reconstitute with 50ul sterile distilled water.)
background: the epidermal growth factor (egf)-tm7 family constitutes a group of class
b g-protein coupled receptors, which includes cd97, emr1 (egf-like molecule containing
mucin-like hormone receptor 1, designated f4/80 in mouse), emr2, emr3, fire, and etl
(1–3). these family members are characterized by an extended extracellular region with
several n-terminal egf domains, and are predominantly expressed on cells of the immune
system (1–3). the egf-tm7 protein family are encoded by a gene cluster on human
chromosome 19p13 (1,3,4). the f4/80 molecule is solely expressed on the surface of
macrophages and serves as a marker for mature macrophage tissues, including kupffer cells
in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and langerhans
cells in the skin (1). f4/80/emr1 undergoes extensive n-linked glycosylation as well as
some o-linked glycosylation (5,6). the function of f4/80/emr1 is unclear, but it is
speculated to be involved in macrophage adhesion events, cell migration, or as a g-protein
coupled signaling component of macrophages.
also known as: f4/80; cell surface glycoprotein emr1; cell surface glycoprotein f4/80;
dd7a5 7; egf like module containing mucin like hormone receptor like 1; egf like module
containing mucin like hormone receptor like sequence 1; egf like module receptor 1; egf
tm7; egf-like module receptor 1; egf-like module-containing mucin-like hormone
receptor-like 1; egftm7; emr 1; emr1; emr-1; emr1 hormone receptor;
emr1_human; gpf480; ly71; lymphocyte antigen 71; tm7ln3.
specificity: -rabbit polyclonal igg, affinity purified by protein a.
-pe conjugated
-reacts with: human,mouse,rat,pig,guinea pig
-immunogen: klh conjugated synthetic peptide derived from human emr1/gpf480.
-predicted molecular weight: 95kda
application: flow-cyt=1:50-200if=1:50-200
excitation spectrum: 520-570nm
emission spectrum: 490-510nm
not yet tested in other applications.
optimal working dilutions must be determined by the end user.
storage: store at -20 °c for one year. avoid repeated freeze/thaw cycles. the lyophilized or liquid antibody is stable at room temperature for at least one month and for greater than a year when kept at -20 °c. when reconstituted in sterile ph 7.4 0.01m pbs or diluent of antibody the antibody is stable for at least two weeks at 2-4 °c.
important note: this product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.