teriflunomide产品活性：teriflunomide是来氟米特的活性代谢产物，是用于治疗类风湿性关节炎的药物。 它抑制嘧啶合成，因此有效降低t细胞和b细胞增殖。
研究领域：others
作用靶点：others
in vitro: teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (dhodh), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. by reducing the activity of high-avidity proliferating t lymphocytes and b lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in ms. thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes.
in vivo: teriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. in the dark agouti rat model of experimental autoimmune encephalitis (eae), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. similarly, in the female lewis rat model of eae, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity.
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