diphenyleneiodonium chloride产品活性：diphenyleneiodonium chloride 是一种 nadph 氧化酶 (nox) 抑制剂，也是一种 trpa1 激活剂，ec50 值在 1 至 3 μm 之间。
研究领域：membrane transporter/ion channel | metabolic enzyme/protease
作用靶点：trp channel | nadph oxidase
in vitro: diphenyleneiodonium chloride is a nadph oxidase (nox) inhibitor and also functions as a trpa1 activator with an ec50 of 1 to 3 μm. application of diphenyleneiodonium chloride to hek-trpa1 cells at a concentration ranges of 0.03 to 10 μm effectively induces a ca2+ response. however, diphenyleneiodonium chloride fails to evoke a ca2+ response in control hek cells, even at a relatively high dose of 10 μm. when diphenyleneiodonium chloride is included in the co-cultures, lipopolysaccharide (lps)-induced preol apoptosis is significantly inhibited. treatment with diphenyleneiodonium chloride is found to significantly attenuate the lps-induced o2- production by 2.0-fold, reducing it to within 27% of the controls.
in vivo: intraplantar injection of 2 mm diphenyleneiodonium chloride to the hindpaw causes licking or biting behavior. diphenyleneiodonium chloride treatment immediately or 24 h after lipopolysaccharide (lps) injection significantly attenuates the lps-induced loss of o4 positive cells. treatment with diphenyleneiodonium chloride either immediately or 24 h after lps injection significantly ameliorates the lps-induced disorganization of the white matter nerve fibers. however, treatment with dpi 48 h after lps injection does not appear to correct the lps-induced white matter damage. dpi treatment either immediately or 24 h after lps injection significantly reduces the accumulation of both gp91phox and p67phox in the membrane fraction.
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