recombinant human interleukin 24(ril-24)
interleukin24(il-24),also known as mda-7 (melanoma differentiationassociatedgene-7), isa newly discovered member of the il-10 familyofhelical cytokines.the il-24geneencodes  158 aa with molecular weightof 18kda.
the glycosylation isessentialforactivity of il-24. functionally, il-24 has diverseactivities.atlow concentrations, it induces type iproinflammatorycytokinessuch as ifn-γ,il-1β, il-12 and tnf-α. athighconcentration, it is a stronginducerof
apoptosisin tumor cells, butnotnormal cells. mda-7/il-24isbeinghailed as a ‘magic bullet’ forcancergenetherapy.
source:adnasequence encodinghuman il-24 (158aminoacids)   wasexpressedinyeastsacharomycescerevisiae.
molecularmass: as aresult ofglycosylation, the recombinant proteinmigratesas
19.5kda protein insds-pageunderreducing conditions.
purity:>98%,as determinedby sds-page and visualized by silverstain.
activity measuredbyitsability to inhibit the cell growth of a549cellsline.ed50 forthiseffect is typically 1.0ng/ml.
formulation lyophilizedfroma0.2 µm filtered solution in pbs.
reconstitution itisrecommendedthat sterile pbs  to prepare astocksolution ofno less than 10µg/ml.
storage lyophilizedsamplesarestable for up to twelve months from date of receipt at-20° c to-70°c. upon reconstitution, this cytokine can bestoredundersterile conditionsat 2° - 8° c for onemonthor at -20° c to -70° cinamanual defrost freezerforthreemonths withoutdetectable loss of activity.

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