阿瑞匹坦
中文名称：阿瑞匹坦；阿瑞吡坦；
英文名称：aprepitant
cas号：170729-80-3
分子式：c23h21f7n4o3
分子量：534.4267
密度：1.51g/cm3
干燥失重：≤0.5%
单个杂质：≤0.5%(hplc)
总杂：≤1.0%(hplc)
纯度：≥99%
外观：白色或类白色粉末
用途：美国fda批准预防化疗相关的恶心和呕吐药
相关产品：阿瑞匹坦侧链，阿瑞匹坦主链
items
specifications
results
appearance
white or off-white powder
conforms
specific rotation
+61°to +74°
+63.0°
identification
rt(hplc)
the retention time of the major peak in the chromatogram of the sample corresponds to that exhibited by the working standard
conforms
residue on ignition
≤0.2%
0.01%
heavy metals
≤20ppm
conforms
enantiomer
by hplc(od-h)
≥99%
99.8%
related compoudds
by hplc(c18)
any single impurity: ≤0.1%
0.09%
total impurities: ≤1.5%
0.2%
residual solvents by gc
 
 
 
 
 
acetonitrile:≤410ppm
97.2ppm
ethyl acetate: ≤5000ppm
510ppm
dimethy lbenzene: ≤2170ppm
450ppm
methanol: ≤3000ppm
n/a
n,n-diisoopropylethylamine: ≤1000ppm
n/a
purity
≥98.5%
99.8%
conclusion: complies with enterprise standard