recombinant human interleukin 8(ril-8)
description:interleukin-8(il-8)belongs to the neutrophil-specific cxc family of chemokines.it isone of the initial cytokines released from a variety of celltypes,including t cells, endothelial cells and
fibroblasts, in response to an inflammatory stimulus and actsbyrecruiting neutrophils, t-cells and
basophils to the site of inflammation. elevated interleukin-8levelsare associated with the
onset of a varietyofdisease states.
recombinantil-8(yeast): a cdnacomprisesthe 79 amino acid fragment (21-99) corresponding to
the mature il-8 protein was transformed into and expressedinyeast(pichia).the 79 aminoacid
fragment is crucial for the formation of two disulfide bridge intheil-8 molecule. upon secretion and n-
terminal processing, the 77 amino cid fragment (23-99)alsopresents. the yeast expressed il-8 was
glycosylated.
purity♦>98%, asdetermined by sds-page analysis.
activity♦chemotacticactivitywas achieved at 25 ng/ml on humanneutrophils.
formulation♦lyophilized froma0.2 µm filteredsolutionin 20 mm sodium phosphate buffer ph6.0
in absence ofanycarrier protein.
storage♦lyophilizedsamplesare stable for greater than six months at-20°cto-70°c.
♦ uponreconstitution,this growth factor can be stored under sterileconditions at2°-4°cforone
month orat-20°cto-70°c forthree monthswithout detectable loss of activity.

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